Preparation method and application of dendritic polymer surface functionalized nano-hydroxyapatite
The invention provides a preparation method and application of dendritic polymer surface functionalized nano-hydroxyapatite, and the preparation method comprises the following steps: S1, mixing a diammonium hydrogen phosphate solution with hexadecyl trimethyl ammonium bromide powder to obtain a modified diammonium hydrogen phosphate solution; s2, dropwise adding the modified diammonium hydrogen phosphate solution into a calcium nitrate solution, and adding ammonia water to obtain a colloidal suspension with a white precipitate; s3, the colloidal suspension is subjected to a reaction under the condition of 160-190 DEG C, and nano-hydroxyapatite is obtained through the reaction; and S4, dissolving the amino-terminated polyamide-amine dendritic polymer in water, and then gradually adding the nano-hydroxyapatite into the amino-terminated polyamide-amine dendritic polymer solution, so as to obtain the dendritic polymer surface functionalized nano-hydroxyapatite. The dendritic polymer surface functionalized nano-hydroxyapatite prepared by the invention can be stabilized on the surface of collagen fiber exposed in a dentinal tubule, so that the exposed dentinal tubule is sealed..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 24. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LIN XUANDONG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-24, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN117105192 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019135998 |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-11-24, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 | ||
| 520 | |a The invention provides a preparation method and application of dendritic polymer surface functionalized nano-hydroxyapatite, and the preparation method comprises the following steps: S1, mixing a diammonium hydrogen phosphate solution with hexadecyl trimethyl ammonium bromide powder to obtain a modified diammonium hydrogen phosphate solution; s2, dropwise adding the modified diammonium hydrogen phosphate solution into a calcium nitrate solution, and adding ammonia water to obtain a colloidal suspension with a white precipitate; s3, the colloidal suspension is subjected to a reaction under the condition of 160-190 DEG C, and nano-hydroxyapatite is obtained through the reaction; and S4, dissolving the amino-terminated polyamide-amine dendritic polymer in water, and then gradually adding the nano-hydroxyapatite into the amino-terminated polyamide-amine dendritic polymer solution, so as to obtain the dendritic polymer surface functionalized nano-hydroxyapatite. The dendritic polymer surface functionalized nano-hydroxyapatite prepared by the invention can be stabilized on the surface of collagen fiber exposed in a dentinal tubule, so that the exposed dentinal tubule is sealed. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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