Antibody targeting monkey pox virus, and antigen binding fragment and application thereof
The invention discloses a monkey pox virus targeting antibody, an antigen binding fragment thereof and application thereof. The antibody or the antigen binding fragment thereof comprises a heavy chain variable region and a light chain variable region or comprises a heavy chain variable region but does not comprise a light chain variable region. The antibody or the antigen binding fragment thereof targets human and non-human primate M1R, the anti-M1R antibody or the antigen binding fragment thereof has improved or reduced affinity, can achieve the purpose of improving the drug effect or reducing the toxicity, can perform selective adaptation according to different target spots when forming a bispecific antibody, and can be used for preparing the bispecific antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody. And a flexible adaptation scheme is provided for drug research and development..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 14. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HUANG LIANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-14, Last update posted on www.tib.eu: 2024-01-29, Last updated: 2024-02-02 |
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| Patentnummer: |
CN117050165 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019118988 |
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| 520 | |a The invention discloses a monkey pox virus targeting antibody, an antigen binding fragment thereof and application thereof. The antibody or the antigen binding fragment thereof comprises a heavy chain variable region and a light chain variable region or comprises a heavy chain variable region but does not comprise a light chain variable region. The antibody or the antigen binding fragment thereof targets human and non-human primate M1R, the anti-M1R antibody or the antigen binding fragment thereof has improved or reduced affinity, can achieve the purpose of improving the drug effect or reducing the toxicity, can perform selective adaptation according to different target spots when forming a bispecific antibody, and can be used for preparing the bispecific antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody or the antigen binding fragment of the antibody. And a flexible adaptation scheme is provided for drug research and development. | ||
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