Preparation of mitoxantrone nano-drug and application of mitoxantrone nano-drug in targeted therapy of pancreatic cancer
The invention relates to preparation of a mitoxantrone nano-drug and application of the mitoxantrone nano-drug in targeted therapy of pancreatic cancer, and belongs to the technical field of biological medicines. Comprising the following steps: adding a mitoxantrone hydrochloride solution into a sodium hyaluronate solution, dialyzing and freeze-drying to obtain mitoxantrone-hyaluronic acid nano-drug powder; the mitoxantrone and the hyaluronic acid are combined to form the mitoxantrone-hyaluronic acid nano targeting drug. The invention provides an application of a mitoxantrone-hyaluronic acid nano-drug in preparation of a pancreatic cancer treatment drug. The mitoxantrone-hyaluronic acid nano-drug has an obvious inhibition effect on pancreatic tumors; the compound has a CD44 receptor targeting property, can effectively reduce the drug toxicity, and enhances the treatment effect on pancreatic cancer tumors at the same time..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 07. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
SHI YUXIN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-07, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN116999575 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019114699 |
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| 520 | |a The invention relates to preparation of a mitoxantrone nano-drug and application of the mitoxantrone nano-drug in targeted therapy of pancreatic cancer, and belongs to the technical field of biological medicines. Comprising the following steps: adding a mitoxantrone hydrochloride solution into a sodium hyaluronate solution, dialyzing and freeze-drying to obtain mitoxantrone-hyaluronic acid nano-drug powder; the mitoxantrone and the hyaluronic acid are combined to form the mitoxantrone-hyaluronic acid nano targeting drug. The invention provides an application of a mitoxantrone-hyaluronic acid nano-drug in preparation of a pancreatic cancer treatment drug. The mitoxantrone-hyaluronic acid nano-drug has an obvious inhibition effect on pancreatic tumors; the compound has a CD44 receptor targeting property, can effectively reduce the drug toxicity, and enhances the treatment effect on pancreatic cancer tumors at the same time. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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