Preparation method of medicine for inhibiting invasion and metastasis of oral cancer cells
The invention discloses a preparation method of a medicine for inhibiting invasion and metastasis of oral cancer cells, and relates to the technical field of oral cancer treatment, and the preparation method specifically comprises the following steps: constructing a CD82 overexpression pulmonary epithelial cell HBE cell strain through genetic engineering, extracting a cell membrane in vitro, modifying an AS1411 aptamer, and preparing the medicine for inhibiting invasion and metastasis of oral cancer cells. The cell membrane source nano vesicles with specific tumor targeting and metastasis inhibition are obtained. The nano vesicle has the functions of specifically targeting tumors and effectively inhibiting metastasis of oral cancer tumor cells, and can effectively overcome the treatment bottleneck of lack of tumor metastasis in the existing oral cancer treatment; in addition, related treatment medicines can directly act on the affected part, so that the treatment effect is improved. The nano-vesicle has multiple effects of specifically targeting malignant breast cancer, inhibiting metastasis, loading a chemotherapeutic drug DOX to induce apoptosis of malignant breast cancer cells and the like..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 03. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHANG XIAOMENG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-03, Last update posted on www.tib.eu: 2024-01-22, Last updated: 2024-01-26 |
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| Patentnummer: |
CN116983433 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019061471 |
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| 245 | 1 | 0 | |a Preparation method of medicine for inhibiting invasion and metastasis of oral cancer cells |
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| 520 | |a The invention discloses a preparation method of a medicine for inhibiting invasion and metastasis of oral cancer cells, and relates to the technical field of oral cancer treatment, and the preparation method specifically comprises the following steps: constructing a CD82 overexpression pulmonary epithelial cell HBE cell strain through genetic engineering, extracting a cell membrane in vitro, modifying an AS1411 aptamer, and preparing the medicine for inhibiting invasion and metastasis of oral cancer cells. The cell membrane source nano vesicles with specific tumor targeting and metastasis inhibition are obtained. The nano vesicle has the functions of specifically targeting tumors and effectively inhibiting metastasis of oral cancer tumor cells, and can effectively overcome the treatment bottleneck of lack of tumor metastasis in the existing oral cancer treatment; in addition, related treatment medicines can directly act on the affected part, so that the treatment effect is improved. The nano-vesicle has multiple effects of specifically targeting malignant breast cancer, inhibiting metastasis, loading a chemotherapeutic drug DOX to induce apoptosis of malignant breast cancer cells and the like. | ||
| 650 | 4 | |a bio | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
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