Foot-and-mouth disease-Seneca bivalent virus-like particle vaccine as well as preparation method and application thereof
The invention discloses a foot-and-mouth disease-Seneca bivalent virus-like particle vaccine as well as a preparation method and application thereof, and belongs to the technical field of animal vaccines and veterinary biological products. The novel bivalent virus-like particle vaccine is prepared by taking foot-and-mouth disease (type O and type A) virus-like particles and Seneca type A virus-like particles as antigens, and the immune synergistic effect and immune efficacy of the bivalent vaccine are evaluated by determining a vaccine preparation process, immune indexes, safety parameters and the like. Experiments prove that the bivalent vaccine has the advantages of strong immunogenicity, good safety, no immune interference and the like, can achieve an immune protection effect equivalent to that of a monovalent vaccine, and is an antigen form most likely to replace a traditional inactivated vaccine. The bivalent virus-like particle vaccine is time-saving, labor-saving and cost-saving in production and application, animal stress can be reduced, the immune effect of'two prevention by one injection 'is achieved, and meanwhile, a more effective vaccine choice is provided for prevention and control of foot-and-mouth disease, Seneca and other virulent diseases..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 03. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
GUO HUICHEN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-03, Last update posted on www.tib.eu: 2024-01-22, Last updated: 2024-01-26 |
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| Patentnummer: |
CN116983402 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA019000634 |
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| 520 | |a The invention discloses a foot-and-mouth disease-Seneca bivalent virus-like particle vaccine as well as a preparation method and application thereof, and belongs to the technical field of animal vaccines and veterinary biological products. The novel bivalent virus-like particle vaccine is prepared by taking foot-and-mouth disease (type O and type A) virus-like particles and Seneca type A virus-like particles as antigens, and the immune synergistic effect and immune efficacy of the bivalent vaccine are evaluated by determining a vaccine preparation process, immune indexes, safety parameters and the like. Experiments prove that the bivalent vaccine has the advantages of strong immunogenicity, good safety, no immune interference and the like, can achieve an immune protection effect equivalent to that of a monovalent vaccine, and is an antigen form most likely to replace a traditional inactivated vaccine. The bivalent virus-like particle vaccine is time-saving, labor-saving and cost-saving in production and application, animal stress can be reduced, the immune effect of'two prevention by one injection 'is achieved, and meanwhile, a more effective vaccine choice is provided for prevention and control of foot-and-mouth disease, Seneca and other virulent diseases. | ||
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