Methods and systems for determining platelet concentration
Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system (100) and a storage medium. The method for determining a platelet concentration in a blood sample includes: forming a first suspension by mixing a first aliquot of the blood sample with a diluent; forming a second suspension by mixing a second aliquot of the blood sample with a lytic agent and a fluorescent dye to lyse red blood cells and stain white blood cells; measuring DC impedance signals of the first suspension passing through an aperture; measuring light scatter signals and fluorescent signals of the second suspension passing through an optical flow cell (20); analyzing DC impedance signals of the first suspension to obtain a first platelet distribution; analyzing light scatter signals and fluorescent signals of the second suspension to differentiate platelets from white blood cells and to obtain a second platelet distribution; and determining platelet data, such as the platelet concentration of the blood sample using the first and second platelet distributions..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Dez. Zur Gesamtaufnahme - year:2023 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
QI HUAN [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-12, Last update posted on www.tib.eu: 2024-01-18, Last updated: 2024-01-26 |
---|
Patentnummer: |
US11841358 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA018857612 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA018857612 | ||
003 | DE-627 | ||
005 | 20240126102033.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231229s2023 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)EPA018857612 | ||
035 | |a (EPA)US11841358 | ||
035 | |a (EPA)68294401 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a QI HUAN |e verfasserin |4 aut | |
245 | 1 | 0 | |a Methods and systems for determining platelet concentration |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), First posted: 2023-12-12, Last update posted on www.tib.eu: 2024-01-18, Last updated: 2024-01-26 | ||
520 | |a Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system (100) and a storage medium. The method for determining a platelet concentration in a blood sample includes: forming a first suspension by mixing a first aliquot of the blood sample with a diluent; forming a second suspension by mixing a second aliquot of the blood sample with a lytic agent and a fluorescent dye to lyse red blood cells and stain white blood cells; measuring DC impedance signals of the first suspension passing through an aperture; measuring light scatter signals and fluorescent signals of the second suspension passing through an optical flow cell (20); analyzing DC impedance signals of the first suspension to obtain a first platelet distribution; analyzing light scatter signals and fluorescent signals of the second suspension to differentiate platelets from white blood cells and to obtain a second platelet distribution; and determining platelet data, such as the platelet concentration of the blood sample using the first and second platelet distributions. | ||
650 | 4 | |a bio | |
650 | 4 | |a tec | |
650 | 4 | |a G16H: Healthcare informatics, i.e. information and communication technology [ict] specially adapted for the handling or processing of medical or healthcare data | |
650 | 4 | |a G01N: Investigating or analysing materials by determining their chemical or physical properties (measuring or testing processes other than immunoassay, involving enzymes or microorganisms c12m, c12q) | |
650 | 4 | |a C12Q: Measuring or testing processes involving enzymes, nucleic acids or microorganisms (immunoassay g01n0033530000); compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | |
650 | 4 | |a 615 | |
700 | 0 | |a YE BO |4 aut | |
700 | 0 | |a ZHENG WENBO |4 aut | |
700 | 0 | |a HU CHANGSONG |4 aut | |
700 | 0 | |a YU QI |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 12. Dez. |
773 | 1 | 8 | |g year:2023 |g day:12 |g month:12 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/68294401/publication/US11841358A1?q=US11841358 |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
936 | u | w | |j 2023 |b 12 |c 12 |
951 | |a AR | ||
952 | |j 2023 |b 12 |c 12 |