Application of long-chain non-coding RNA (Ribonucleic Acid) as novel AS (Activated Sequence) marker
The invention relates to application of a long-chain non-coding RNA (Ribonucleic Acid) as a novel AS (Activated Sequence) marker, belonging to the field of molecular biology of rheumatism, and a primer for detecting the long-chain non-coding RNA AC105046.1 can be applied to an AS auxiliary diagnosis or curative effect prediction reagent. A specific overexpression sequence and a small interference sequence RNA sequence synthesized according to the full-length sequence of the long-chain non-coding RNA can be applied to an AS targeted therapeutic reagent. The expression of the long-chain non-coding RNA in AS is significantly down-regulated, is inversely proportional to clinical inflammation and platelets, and is in direct proportion to prothrombin time. According to the present invention, with the overexpression of the AC105046.1, the expression level of the AC105046.1 in AS-FLS (AS-PBMC and physiological FLS co-culture) cells can be significantly increased, the expression of inflammatory cytokines in the co-culture AS-FLS can be inhibited, and the expression of the procoagulant index can be inhibited;.
Medienart: |
Patent |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Europäisches Patentamt - (2023) vom: 29. Sept. Zur Gesamtaufnahme - year:2023 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
LIU JIAN [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-29, Last update posted on www.tib.eu: 2023-12-19, Last updated: 2023-12-22 |
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Patentnummer: |
CN116814776 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA018802141 |
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520 | |a The invention relates to application of a long-chain non-coding RNA (Ribonucleic Acid) as a novel AS (Activated Sequence) marker, belonging to the field of molecular biology of rheumatism, and a primer for detecting the long-chain non-coding RNA AC105046.1 can be applied to an AS auxiliary diagnosis or curative effect prediction reagent. A specific overexpression sequence and a small interference sequence RNA sequence synthesized according to the full-length sequence of the long-chain non-coding RNA can be applied to an AS targeted therapeutic reagent. The expression of the long-chain non-coding RNA in AS is significantly down-regulated, is inversely proportional to clinical inflammation and platelets, and is in direct proportion to prothrombin time. According to the present invention, with the overexpression of the AC105046.1, the expression level of the AC105046.1 in AS-FLS (AS-PBMC and physiological FLS co-culture) cells can be significantly increased, the expression of inflammatory cytokines in the co-culture AS-FLS can be inhibited, and the expression of the procoagulant index can be inhibited; | ||
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