MULTIFUNCTIONAL ANTIBODIES
The present invention concerns multifunctional antibody construct containing at least one antibody Ab and two distinct payloads D1 and D2 of structure (1) or (2). Wherein L1, L2, L3, L4 and L5 are linkers; x1 and x2 are each individually an integer in the range of 1 – 8, wherein x1 + x2 = 2 - 10; BM is a branching moiety; m and n are each independently 0 or 1; x3 is an integer in the range of 1 - 4; and D1 and D2 are two distinct payloads selected from the group consisting of polypeptides, small molecules, cytotoxins and oligonucleotides, wherein at least one of D1 and D2 is a polypeptide. The multifunctional antibody construct according to invention are suitable for use in medicine, such as for use in the treatment of cancer, a viral infection, a bacterial infection, a neurological disease, an autoimmune disease, an eye disease, hypercholesterolemia and amyloidosis..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 13. Dez. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
VAN GEEL REMON [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Sonstige Themen: |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-13, Last update posted on www.tib.eu: 2024-02-27, Last updated: 2024-03-01 |
|---|
| Patentnummer: |
EP4288108 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA018774040 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA018774040 | ||
| 003 | DE-627 | ||
| 005 | 20240301101812.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231222s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA018774040 | ||
| 035 | |a (EPA)EP4288108 | ||
| 035 | |a (EPA)74666428 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a VAN GEEL REMON |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a MULTIFUNCTIONAL ANTIBODIES |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-12-13, Last update posted on www.tib.eu: 2024-02-27, Last updated: 2024-03-01 | ||
| 520 | |a The present invention concerns multifunctional antibody construct containing at least one antibody Ab and two distinct payloads D1 and D2 of structure (1) or (2). Wherein L1, L2, L3, L4 and L5 are linkers; x1 and x2 are each individually an integer in the range of 1 – 8, wherein x1 + x2 = 2 - 10; BM is a branching moiety; m and n are each independently 0 or 1; x3 is an integer in the range of 1 - 4; and D1 and D2 are two distinct payloads selected from the group consisting of polypeptides, small molecules, cytotoxins and oligonucleotides, wherein at least one of D1 and D2 is a polypeptide. The multifunctional antibody construct according to invention are suitable for use in medicine, such as for use in the treatment of cancer, a viral infection, a bacterial infection, a neurological disease, an autoimmune disease, an eye disease, hypercholesterolemia and amyloidosis. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a WIJDEVEN MARIA ANTONIA |4 aut | |
| 700 | 0 | |a VUGS WILLEM JOHANNES PETRUS |4 aut | |
| 700 | 0 | |a DE BEVER LAUREEN |4 aut | |
| 700 | 0 | |a POPAL SORRAYA |4 aut | |
| 700 | 0 | |a HOOGENBOOM JORIN |4 aut | |
| 700 | 0 | |a VAN BERKEL SANDER SEBASTIAAN |4 aut | |
| 700 | 0 | |a VAN DELFT FLORIS LOUIS |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 13. Dez. |
| 773 | 1 | 8 | |g year:2023 |g day:13 |g month:12 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/74666428/publication/EP4288108A1?q=EP4288108 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 13 |c 12 | ||