Multifunctional antibody
The present invention relates to multifunctional antibody constructs comprising at least one antibody Ab and two different payloads D1 and D2, said constructs having the structure (1) or (2). Wherein L1, L2, L3, L4 and L5 are joints; x1 and x2 are each independently an integer in the range of 1-8, wherein x1 + x2 = 2-10; bM is a branched chain part; m and n are each independently 0 or 1; x3 is an integer in the range of 1-4; d1 and D2 are two different payloads selected from the group consisting of polypeptides, small molecules, cytotoxins and oligonucleotides, wherein at least one of D1 and D2 is a polypeptide. The multifunctional antibody constructs according to the invention are suitable for use in medicine, for example in the treatment of cancer, viral infections, bacterial infections, nervous system diseases, autoimmune diseases, ocular diseases, hypercholesterolemia and amyloidosis. # imgabs0 #.
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 01. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
VAN GEEL REMON [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-01, Last update posted on www.tib.eu: 2024-02-26, Last updated: 2024-03-01 |
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| Patentnummer: |
CN117157107 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018726674 |
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| 520 | |a The present invention relates to multifunctional antibody constructs comprising at least one antibody Ab and two different payloads D1 and D2, said constructs having the structure (1) or (2). Wherein L1, L2, L3, L4 and L5 are joints; x1 and x2 are each independently an integer in the range of 1-8, wherein x1 + x2 = 2-10; bM is a branched chain part; m and n are each independently 0 or 1; x3 is an integer in the range of 1-4; d1 and D2 are two different payloads selected from the group consisting of polypeptides, small molecules, cytotoxins and oligonucleotides, wherein at least one of D1 and D2 is a polypeptide. The multifunctional antibody constructs according to the invention are suitable for use in medicine, for example in the treatment of cancer, viral infections, bacterial infections, nervous system diseases, autoimmune diseases, ocular diseases, hypercholesterolemia and amyloidosis. # imgabs0 # | ||
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