Immune-enhanced fusion protein for expressing TGF [beta] RII and TIM3 extracellular regions and application thereof
The invention discloses a fusion protein capable of simultaneously intervening in TGF beta RII and TIM3 mediated signaling pathways, namely, TGF beta RII and TIM3 extracellular regions are expressed on a cell therapy product, so that the inhibition effect of a tumor microenvironment is relieved, the immunocompetence is maintained, and a foundation is laid for immunotherapy of advanced tumors..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
XU ZHENYU [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-12, Last update posted on www.tib.eu: 2023-12-19, Last updated: 2023-12-22 |
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| Patentnummer: |
CN116731205 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018694896 |
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| 245 | 1 | 0 | |a Immune-enhanced fusion protein for expressing TGF [beta] RII and TIM3 extracellular regions and application thereof |
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| 520 | |a The invention discloses a fusion protein capable of simultaneously intervening in TGF beta RII and TIM3 mediated signaling pathways, namely, TGF beta RII and TIM3 extracellular regions are expressed on a cell therapy product, so that the inhibition effect of a tumor microenvironment is relieved, the immunocompetence is maintained, and a foundation is laid for immunotherapy of advanced tumors. | ||
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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