T lymphocyte and applications thereof
Provided is a T lymphocyte. The T lymphocyte expresses a chimeric antigen receptor, and includes an extracellular region. The extracellular region includes a first single-chain antibody, a second single-chain antibody, a first linker peptide, and a CD8 hinge region. The first linker peptide is arranged between the first single-chain antibody and the second single-chain antibody. The first single-chain antibody includes a first heavy chain variable region, a first light chain variable region, and a second linker peptide. The second linker peptide is arranged between the first heavy chain variable region and the first light chain variable region. The second single-chain antibody includes a second heavy chain variable region, a second light chain variable region, and a third linker peptide. The third linker peptide is arranged between the second heavy chain variable region and the second light chain variable region. The first linker peptide has a repeated amino acid sequence of GGGGS, and the second linker peptide and the third linker peptide independently have 2-6 repeated amino acid sequences of GGGGS, respectively..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 16. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
DU XIAOLONG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-16, Last update posted on www.tib.eu: 2024-03-06, Last updated: 2024-03-08 |
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| Patentnummer: |
US2023364136 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018655475 |
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| 520 | |a Provided is a T lymphocyte. The T lymphocyte expresses a chimeric antigen receptor, and includes an extracellular region. The extracellular region includes a first single-chain antibody, a second single-chain antibody, a first linker peptide, and a CD8 hinge region. The first linker peptide is arranged between the first single-chain antibody and the second single-chain antibody. The first single-chain antibody includes a first heavy chain variable region, a first light chain variable region, and a second linker peptide. The second linker peptide is arranged between the first heavy chain variable region and the first light chain variable region. The second single-chain antibody includes a second heavy chain variable region, a second light chain variable region, and a third linker peptide. The third linker peptide is arranged between the second heavy chain variable region and the second light chain variable region. The first linker peptide has a repeated amino acid sequence of GGGGS, and the second linker peptide and the third linker peptide independently have 2-6 repeated amino acid sequences of GGGGS, respectively. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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