VIA CYCLOADDITION BILATERALLY FUNCTIONALIZED ANTIBODIES
The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate having structure (1): wherein:a, b and c are each independently 0 or 1;L1, L2 and L3 are linkers;D is a payload;BM is a branching moiety;Z are connecting groups obtainable by a cycloaddition reaction.The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 16. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
VAN DELFT FLORIS LOUIS [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-16, Last update posted on www.tib.eu: 2023-12-07, Last updated: 2023-12-15 |
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| Patentnummer: |
US2023364262 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018607012 |
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| 520 | |a The present invention provides antibody-payload conjugates having a payload-to-antibody ratio of 1. The antibody-payload conjugate having structure (1): wherein:a, b and c are each independently 0 or 1;L1, L2 and L3 are linkers;D is a payload;BM is a branching moiety;Z are connecting groups obtainable by a cycloaddition reaction.The invention further provides a method for preparing the antibody-payload conjugate according to the invention, an intermediate compound in that preparation method, and medical uses of the antibody-payload conjugate according to the invention. | ||
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