CAMPTOTHECIN DERIVATIVE, ANTIBODY-DRUG CONJUGATE AND PHARMACEUTICAL COMPOSITION BASED ON SAME, AND USE THEREOF
The present invention belongs to the field of pharmaceutical chemistry, and relates to a camptothecin derivative, an antibody-drug conjugate and pharmaceutical composition based on same, and the use thereof. The derivative has a structure as represented by formula (I), has a good inhibitory activity on DNA topoisomerase (I) and a tumor cell killing effect, so that the derivative can be used for preventing and/or treating diseases (such as cancer) that are at least partially related to TOP1, and has great development prospects..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 16. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
JIANG SHANJUN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-16, Last update posted on www.tib.eu: 2024-02-23, Last updated: 2024-03-01 |
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| Patentnummer: |
WO2023217064 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018603149 |
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| 520 | |a The present invention belongs to the field of pharmaceutical chemistry, and relates to a camptothecin derivative, an antibody-drug conjugate and pharmaceutical composition based on same, and the use thereof. The derivative has a structure as represented by formula (I), has a good inhibitory activity on DNA topoisomerase (I) and a tumor cell killing effect, so that the derivative can be used for preventing and/or treating diseases (such as cancer) that are at least partially related to TOP1, and has great development prospects. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
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