3-amino-5-phenyl-pyrazole derivative tubulin inhibitor as well as preparation and medical application thereof
The invention provides a 3-amino-5-phenyl-pyrazole derivative tubulin inhibitor and preparation and medical application thereof, the structure of the 3-amino-5-phenyl-pyrazole derivative is shown as a formula (I), in the formula (I), R1 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl, R2 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl, and R3 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl; r2 and R3 are independently selected from methyl, methoxyl, fluorine, chlorine or bromine. The compound not only has strong anti-tumor activity, but also has an anti-angiogenesis effect, can effectively inhibit proliferation of tumor cells, and can be used for preparing a tumor proliferation inhibitor. Moreover, the tubulin inhibitor has very strong capability of inhibiting aggregation of tubulin, and a novel tubulin inhibitor is provided for inhibiting proliferation of tumor cells..
Medienart: |
Patent |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Europäisches Patentamt - (2023) vom: 04. Aug. Zur Gesamtaufnahme - year:2023 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
LI CAOLONG [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-04, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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Patentnummer: |
CN116535356 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA018559581 |
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520 | |a The invention provides a 3-amino-5-phenyl-pyrazole derivative tubulin inhibitor and preparation and medical application thereof, the structure of the 3-amino-5-phenyl-pyrazole derivative is shown as a formula (I), in the formula (I), R1 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl, R2 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl, and R3 is independently selected from 3, 4, 5-trimethoxy phenyl, 3, 4-dimethoxy phenyl or dioxolane [1, 3-d] phenyl; r2 and R3 are independently selected from methyl, methoxyl, fluorine, chlorine or bromine. The compound not only has strong anti-tumor activity, but also has an anti-angiogenesis effect, can effectively inhibit proliferation of tumor cells, and can be used for preparing a tumor proliferation inhibitor. Moreover, the tubulin inhibitor has very strong capability of inhibiting aggregation of tubulin, and a novel tubulin inhibitor is provided for inhibiting proliferation of tumor cells. | ||
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