Nano-drug for cis-platinum drug-resistant tumor glutamine interference therapy as well as preparation method and application of nano-drug
The invention provides a nano-drug for cis-platinum drug-resistant tumor glutamine interference therapy as well as a preparation method and application of the nano-drug. The nano-drug comprises a seed kernel and an amphiphilic shell. The seed inner core comprises cis-platinum and a glutamine inhibitor 6-diazo-5-oxo-L-n-leucine, the amphiphilic shell is hydrophilic polymer hyaluronic acid modified by a hydrophobic molecule 2-nitroimidazole, and the seed inner core and the amphiphilic shell form nano-particles in a self-assembly mode. The glutamine interference therapy nano-drug for the cis-platinum drug-resistant tumors is prepared by carrying out self-assembly on the glutamine interference therapy nano-drug, cis-platinum and 6-diazo-5-oxo-L-n-leucine in an aqueous solution to obtain the glutamine interference therapy nano-drug for the cis-platinum drug-resistant tumors. The nano-drug provided by the invention has hypoxia response performance, and can realize specific release of the drug at a cis-platinum drug-resistant tumor site..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 04. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
CHEN JING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-04, Last update posted on www.tib.eu: 2023-11-14, Last updated: 2023-11-17 |
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| Patentnummer: |
CN116531346 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018554067 |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-08-04, Last update posted on www.tib.eu: 2023-11-14, Last updated: 2023-11-17 | ||
| 520 | |a The invention provides a nano-drug for cis-platinum drug-resistant tumor glutamine interference therapy as well as a preparation method and application of the nano-drug. The nano-drug comprises a seed kernel and an amphiphilic shell. The seed inner core comprises cis-platinum and a glutamine inhibitor 6-diazo-5-oxo-L-n-leucine, the amphiphilic shell is hydrophilic polymer hyaluronic acid modified by a hydrophobic molecule 2-nitroimidazole, and the seed inner core and the amphiphilic shell form nano-particles in a self-assembly mode. The glutamine interference therapy nano-drug for the cis-platinum drug-resistant tumors is prepared by carrying out self-assembly on the glutamine interference therapy nano-drug, cis-platinum and 6-diazo-5-oxo-L-n-leucine in an aqueous solution to obtain the glutamine interference therapy nano-drug for the cis-platinum drug-resistant tumors. The nano-drug provided by the invention has hypoxia response performance, and can realize specific release of the drug at a cis-platinum drug-resistant tumor site. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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| 650 | 4 | |a B82Y: Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | |
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