Glucose-responsive polyamino acid multifunctional nano-vesicle as well as preparation and application thereof
The invention relates to the technical field of intelligent materials, in particular to glucose-responsive polyamino acid multifunctional nanoparticles and a preparation method and application thereof. The invention provides a polyamino acid multifunctional nano particle. The polyamino acid multifunctional nano particle comprises a polyamino acid derivative and glucose oxidase, the structure of the polyamino acid derivative is shown as a formula I. According to the sugar-responsive polyamino acid multifunctional nano-vesicle provided by the invention, the obtained nano-material has excellent sugar sensitivity, the structure and the function of the nano-material can be changed under a high-sugar condition, and the nano-material has high specificity and strong controllability, also has long-acting cycle performance, and effectively avoids the risk of hypoglycemia; the body fluorescence property endows the probe with excellent tracing performance; and the preparation method is simple, and the biocompatibility is good. Therefore, the nano-material has good application potential in the fields of self-assembly, biosensing, drug delivery, disease diagnosis and treatment and the like..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 22. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
YAN YUE [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-22, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116617185 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018528414 |
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| 520 | |a The invention relates to the technical field of intelligent materials, in particular to glucose-responsive polyamino acid multifunctional nanoparticles and a preparation method and application thereof. The invention provides a polyamino acid multifunctional nano particle. The polyamino acid multifunctional nano particle comprises a polyamino acid derivative and glucose oxidase, the structure of the polyamino acid derivative is shown as a formula I. According to the sugar-responsive polyamino acid multifunctional nano-vesicle provided by the invention, the obtained nano-material has excellent sugar sensitivity, the structure and the function of the nano-material can be changed under a high-sugar condition, and the nano-material has high specificity and strong controllability, also has long-acting cycle performance, and effectively avoids the risk of hypoglycemia; the body fluorescence property endows the probe with excellent tracing performance; and the preparation method is simple, and the biocompatibility is good. Therefore, the nano-material has good application potential in the fields of self-assembly, biosensing, drug delivery, disease diagnosis and treatment and the like. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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