Application of 3-TYP in preparation of medicine for treating autoimmune demyelination disease
The invention belongs to the technical field of medicines, and discloses application of 3-TYP shown in a formula (I) in preparation of medicines for preventing, relieving and/or treating autoimmune demyelination diseases. In a mouse experimental autoimmune encephalomyelitis model, the 3-TYP shows a good treatment effect, and can effectively treat pathological changes and progression of diseases. The therapeutic effect is achieved by relieving spinal cord inflammatory cell infiltration and reducing spinal cord demyelination, and relieving spinal cord inflammation and inhibiting generation of proinflammatory factors may be achieved by adjusting the polarization state of M1/M2 type microglial cells..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 29. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
DU GUANHUA [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-29, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116650482 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA01852317X |
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| 520 | |a The invention belongs to the technical field of medicines, and discloses application of 3-TYP shown in a formula (I) in preparation of medicines for preventing, relieving and/or treating autoimmune demyelination diseases. In a mouse experimental autoimmune encephalomyelitis model, the 3-TYP shows a good treatment effect, and can effectively treat pathological changes and progression of diseases. The therapeutic effect is achieved by relieving spinal cord inflammatory cell infiltration and reducing spinal cord demyelination, and relieving spinal cord inflammation and inhibiting generation of proinflammatory factors may be achieved by adjusting the polarization state of M1/M2 type microglial cells. | ||
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