Application of BET inhibitor in preparation of melanoma immunoadjuvant therapy medicine
The invention provides an application of a BET inhibitor in enhancing the immunotherapy effect of melanoma. The invention also provides the application of the BET inhibitor and the ferroptosis inducer in the treatment of melanoma. The BET inhibitor down-regulates the expression of the ferroptosis resistance gene AKR1C2 through a dual mechanism so as to sensitize melanoma ferroptosis. The dual mechanism is specifically as follows: a BET inhibitor is competitively combined with a target BRD4 protein, the combination of the BRD4 protein and an AKR1C2 gene promoter is inhibited, and the transcriptional expression of AKR1C2 is reduced; and the expression of AKR1C2 is indirectly regulated and controlled through a BRD4/IL6/STAT3 signal axis. The invention provides a thought for a melanoma combined treatment strategy of BET inhibitor and immunotherapy..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
DENG GUANGTONG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-15, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116585474 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018475973 |
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| 520 | |a The invention provides an application of a BET inhibitor in enhancing the immunotherapy effect of melanoma. The invention also provides the application of the BET inhibitor and the ferroptosis inducer in the treatment of melanoma. The BET inhibitor down-regulates the expression of the ferroptosis resistance gene AKR1C2 through a dual mechanism so as to sensitize melanoma ferroptosis. The dual mechanism is specifically as follows: a BET inhibitor is competitively combined with a target BRD4 protein, the combination of the BRD4 protein and an AKR1C2 gene promoter is inhibited, and the transcriptional expression of AKR1C2 is reduced; and the expression of AKR1C2 is indirectly regulated and controlled through a BRD4/IL6/STAT3 signal axis. The invention provides a thought for a melanoma combined treatment strategy of BET inhibitor and immunotherapy. | ||
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