Nano-drug for opening blood-brain barrier along with phospholipase A2, preparation method of nano-drug and application of nano-drug in resisting nerve toxic agent poisoning
The invention belongs to the field of medicines, and particularly relates to a nano-drug for treating cerebral diseases, in particular to a related drug for treating acute cerebral poisoning. The medicine is formed by loading an acetylcholin esterase heavy activator on spherical nano-particles formed by phosphatidylserine and assisting with phospholipase A2. The compound can effectively penetrate through the blood brain barrier to rapidly release drugs to the central nervous system, is high in reactivation rate of acetylcholin esterase, is simple and convenient to prepare, and can be used for rapidly treating organophosphorus compound poisoning of the central nervous system. The invention also relates to a preparation method and application of the nano-drug..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG YONGAN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-15, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116585287 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018467105 |
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| 520 | |a The invention belongs to the field of medicines, and particularly relates to a nano-drug for treating cerebral diseases, in particular to a related drug for treating acute cerebral poisoning. The medicine is formed by loading an acetylcholin esterase heavy activator on spherical nano-particles formed by phosphatidylserine and assisting with phospholipase A2. The compound can effectively penetrate through the blood brain barrier to rapidly release drugs to the central nervous system, is high in reactivation rate of acetylcholin esterase, is simple and convenient to prepare, and can be used for rapidly treating organophosphorus compound poisoning of the central nervous system. The invention also relates to a preparation method and application of the nano-drug. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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