Polypeptide or derivative thereof and application thereof in preparation of medicine for treating fatty liver disease
The invention belongs to the field of biological medicines, and discloses a polypeptide or a derivative thereof and an application of the polypeptide or the derivative in preparation of a medicine for treating fatty liver diseases. The amino acid sequence of the polypeptide R2 is shown as SEQ ID NO: 1, and the polypeptide R2 can be specifically combined with STUB1, so that interaction of STUB1/RAB27A is blocked, RAB27A protein expression is reduced, macrophage exosome secretion is reduced, and hepatic cell lipid deposition is reduced, and therefore, the polypeptide R2 is applied to preparation of drugs for treating the non-alcoholic fatty liver disease. The polypeptide and/or the polypeptide derivative thereof are/is remarkable in curative effect on the non-alcoholic fatty liver disease, small in toxic and side effects and safe to use..
| Medienart: |
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 08. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LIU SHANSHAN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-08, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116554275 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018466761 |
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| 520 | |a The invention belongs to the field of biological medicines, and discloses a polypeptide or a derivative thereof and an application of the polypeptide or the derivative in preparation of a medicine for treating fatty liver diseases. The amino acid sequence of the polypeptide R2 is shown as SEQ ID NO: 1, and the polypeptide R2 can be specifically combined with STUB1, so that interaction of STUB1/RAB27A is blocked, RAB27A protein expression is reduced, macrophage exosome secretion is reduced, and hepatic cell lipid deposition is reduced, and therefore, the polypeptide R2 is applied to preparation of drugs for treating the non-alcoholic fatty liver disease. The polypeptide and/or the polypeptide derivative thereof are/is remarkable in curative effect on the non-alcoholic fatty liver disease, small in toxic and side effects and safe to use. | ||
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