Application of litchi pericarp alcohol extract in preparation of anti-inflammatory medicine and preparation method of litchi pericarp alcohol extract
The invention discloses application of a litchi pericarp alcohol extract in preparation of an anti-inflammatory medicine and a preparation method of the litchi pericarp alcohol extract. In the invention, the anti-inflammatory litchi pericarp alcohol extract is obtained by extracting litchi pericarp with 70% ethanol, and the litchi pericarp alcohol extract inhibits the generation of LPS-induced pro-inflammatory mediators (NO) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) under the condition of no cytotoxicity; the litchi pericarp alcohol extract inhibits transcription of LPS-induced pro-inflammatory cytokine genes and expression of genes and proteins for synthesizing pro-inflammatory mediator enzymes (iNOS and COX-2); the litchi pericarp alcohol extract not only inhibits nuclear transfer of NF-kappa B by reducing phosphorylation and degradation of I kappa B alpha, but also inhibits phosphorylation of MPAKs (ERK, p38 and JNK); the compound has a remarkable inhibition effect on foot swelling induced by carrageenan, and has a remarkable anti-inflammatory effect in vivo and in vitro..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 04. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HONG YI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-08-04, Last update posted on www.tib.eu: 2023-12-05, Last updated: 2023-12-08 |
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| Patentnummer: |
CN116531440 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018450024 |
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| 520 | |a The invention discloses application of a litchi pericarp alcohol extract in preparation of an anti-inflammatory medicine and a preparation method of the litchi pericarp alcohol extract. In the invention, the anti-inflammatory litchi pericarp alcohol extract is obtained by extracting litchi pericarp with 70% ethanol, and the litchi pericarp alcohol extract inhibits the generation of LPS-induced pro-inflammatory mediators (NO) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) under the condition of no cytotoxicity; the litchi pericarp alcohol extract inhibits transcription of LPS-induced pro-inflammatory cytokine genes and expression of genes and proteins for synthesizing pro-inflammatory mediator enzymes (iNOS and COX-2); the litchi pericarp alcohol extract not only inhibits nuclear transfer of NF-kappa B by reducing phosphorylation and degradation of I kappa B alpha, but also inhibits phosphorylation of MPAKs (ERK, p38 and JNK); the compound has a remarkable inhibition effect on foot swelling induced by carrageenan, and has a remarkable anti-inflammatory effect in vivo and in vitro. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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