PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 01. Nov. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
PALA DANIELE [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-01, Last update posted on www.tib.eu: 2023-11-15, Last updated: 2023-11-24 |
|---|
| Patentnummer: |
EP4267584 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA018399401 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA018399401 | ||
| 003 | DE-627 | ||
| 005 | 20231124095015.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231110s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA018399401 | ||
| 035 | |a (EPA)EP4267584 | ||
| 035 | |a (EPA)73943132 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a PALA DANIELE |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-11-01, Last update posted on www.tib.eu: 2023-11-15, Last updated: 2023-11-24 | ||
| 520 | |a The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a PIZZIRANI DANIELA |4 aut | |
| 700 | 0 | |a BRUNO PAOLO |4 aut | |
| 700 | 0 | |a BIAGETTI MATTEO |4 aut | |
| 700 | 0 | |a RONCHI PAOLO |4 aut | |
| 700 | 0 | |a GUARIENTO SARA |4 aut | |
| 700 | 0 | |a BERTANI BARBARA |4 aut | |
| 700 | 0 | |a RESCIGNO DONATELLA |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 01. Nov. |
| 773 | 1 | 8 | |g year:2023 |g day:01 |g month:11 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/73943132/publication/EP4267584A1?q=EP4267584 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 936 | u | w | |j 2023 |b 01 |c 11 |
| 951 | |a AR | ||
| 952 | |j 2023 |b 01 |c 11 | ||