Diaryl urea PI3K/mTOR/HDAC multi-target inhibitor as well as pharmaceutical composition and application thereof
The invention belongs to the technical field of medicines, and particularly relates to a diarylurea PI3K/mTOR/HDAC multi-target inhibitor as well as a pharmaceutical composition and application of the diarylurea PI3K/mTOR/HDAC multi-target inhibitor. The diarylurea PI3K/mTOR/HDAC multi-target inhibitor disclosed by the invention belongs to a single-molecule multi-target inhibitor, has multiple action mechanisms, and has the characteristics of good curative effect and small toxicity. The compound has the characteristic of effectively inhibiting a plurality of PI3K subtype kinases, mTOR kinases and HDAC proteins. The structure of the diarylurea PI3K/mTOR/HDAC multi-target inhibitor is as shown in the specification..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Mai Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHANG JIQUAN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-05-12, Last update posted on www.tib.eu: 2023-10-31, Last updated: 2023-11-03 |
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| Patentnummer: |
CN116102545 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018336108 |
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| 520 | |a The invention belongs to the technical field of medicines, and particularly relates to a diarylurea PI3K/mTOR/HDAC multi-target inhibitor as well as a pharmaceutical composition and application of the diarylurea PI3K/mTOR/HDAC multi-target inhibitor. The diarylurea PI3K/mTOR/HDAC multi-target inhibitor disclosed by the invention belongs to a single-molecule multi-target inhibitor, has multiple action mechanisms, and has the characteristics of good curative effect and small toxicity. The compound has the characteristic of effectively inhibiting a plurality of PI3K subtype kinases, mTOR kinases and HDAC proteins. The structure of the diarylurea PI3K/mTOR/HDAC multi-target inhibitor is as shown in the specification. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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