ANTIBODY-CONJUGATES FOR TARGETING OF TUMOURS EXPRESSING PTK7
The present invention concerns antibody-conjugates which are especially suitable for the targeting of PTK7-expressing cells, in particular tumour cells. The antibody-conjugates according to the invention have structure (1): AB-[(L6)b͟-{Z-L-D}x]y (1) Herein, AB is an antibody capable of targeting PTK7-expressing tumours; L is a linker that links Z to D; Z is a connecting group; L6 is –GlcNAc(Fuc)w-(G)j-S-(L7)w'-, wherein G is a monosaccharide, j is an integer in the range of 0 – 10, S is a sugar or a sugar derivative, GlcNAc is N- acetylglucosamine and Fuc is fucose, w is 0 or 1, w' is 0, 1 or 2 and L7 is _N(H)C(O)CH2-, -N(H)C(O)CF2- or -CH2-; D is selected from the group consisting of anthracyclines, camptothecins, tubulysins, enediynes, amanitins, duocarmycins, maytansinoids, auristatins, eribulins, BCL-XL inhibitors, hemiasterlins, KSP inhibitors, TLR agonists, indolinobenzodiazepine dimers or pyrrolobenzodiazepine dimers (PBDs), and analogues or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further concerns a method for preparing the antibody- conjugates of structure (1) and application of the antibody-conjugates of structure (1)..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 28. Sept. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
LELIEVELDT LIANNE [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Sonstige Themen: |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-28, Last update posted on www.tib.eu: 2023-10-19, Last updated: 2023-10-27 |
|---|
| Patentnummer: |
WO2023180484 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA018261485 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA018261485 | ||
| 003 | DE-627 | ||
| 005 | 20231027104434.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231020s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA018261485 | ||
| 035 | |a (EPA)WO2023180484 | ||
| 035 | |a (EPA)81308370 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a LELIEVELDT LIANNE |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a ANTIBODY-CONJUGATES FOR TARGETING OF TUMOURS EXPRESSING PTK7 |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-09-28, Last update posted on www.tib.eu: 2023-10-19, Last updated: 2023-10-27 | ||
| 520 | |a The present invention concerns antibody-conjugates which are especially suitable for the targeting of PTK7-expressing cells, in particular tumour cells. The antibody-conjugates according to the invention have structure (1): AB-[(L6)b͟-{Z-L-D}x]y (1) Herein, AB is an antibody capable of targeting PTK7-expressing tumours; L is a linker that links Z to D; Z is a connecting group; L6 is –GlcNAc(Fuc)w-(G)j-S-(L7)w'-, wherein G is a monosaccharide, j is an integer in the range of 0 – 10, S is a sugar or a sugar derivative, GlcNAc is N- acetylglucosamine and Fuc is fucose, w is 0 or 1, w' is 0, 1 or 2 and L7 is _N(H)C(O)CH2-, -N(H)C(O)CF2- or -CH2-; D is selected from the group consisting of anthracyclines, camptothecins, tubulysins, enediynes, amanitins, duocarmycins, maytansinoids, auristatins, eribulins, BCL-XL inhibitors, hemiasterlins, KSP inhibitors, TLR agonists, indolinobenzodiazepine dimers or pyrrolobenzodiazepine dimers (PBDs), and analogues or prodrugs thereof; b is 0 or 1; x is 1 or 2; and y is 1, 2, 3 or 4. The invention further concerns a method for preparing the antibody- conjugates of structure (1) and application of the antibody-conjugates of structure (1). | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a VAN GEEL REMON |4 aut | |
| 700 | 0 | |a VAN BERKEL SANDER SEBASTIAAN |4 aut | |
| 700 | 0 | |a VAN DELFT FLORIS LOUIS |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 28. Sept. |
| 773 | 1 | 8 | |g year:2023 |g day:28 |g month:09 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/81308370/publication/WO2023180484A1?q=WO2023180484 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 936 | u | w | |j 2023 |b 28 |c 09 |
| 951 | |a AR | ||
| 952 | |j 2023 |b 28 |c 09 | ||