CELL-PENETRATING PEPTIDE CONJUGATES AND METHODS OF THEIR USE
Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 28. Sept. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
WOOD MATTHEW [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-28, Last update posted on www.tib.eu: 2024-02-26, Last updated: 2024-03-01 |
|---|
| Patentnummer: |
AU2022220252 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA018158463 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA018158463 | ||
| 003 | DE-627 | ||
| 005 | 20240301100645.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231013s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA018158463 | ||
| 035 | |a (EPA)AU2022220252 | ||
| 035 | |a (EPA)74669201 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a WOOD MATTHEW |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CELL-PENETRATING PEPTIDE CONJUGATES AND METHODS OF THEIR USE |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-09-28, Last update posted on www.tib.eu: 2024-02-26, Last updated: 2024-03-01 | ||
| 520 | |a Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene. | ||
| 650 | 4 | |a bio | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
| 650 | 4 | |a che | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a MANZANO RAQUEL |4 aut | |
| 700 | 0 | |a GODFREY CAROLINE |4 aut | |
| 700 | 0 | |a MCCLOREY GRAHAM |4 aut | |
| 700 | 0 | |a RAZ RICHARD |4 aut | |
| 700 | 0 | |a GAIT MICHAEL |4 aut | |
| 700 | 0 | |a ARZUMANOV ANDREY |4 aut | |
| 700 | 0 | |a O'DONOVAN LIZ |4 aut | |
| 700 | 0 | |a HAZELL GARETH |4 aut | |
| 700 | 0 | |a HOLLAND ASHLING |4 aut | |
| 700 | 0 | |a VARELA MIGUEL |4 aut | |
| 700 | 0 | |a BANERJEE SUBHASHIS |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 28. Sept. |
| 773 | 1 | 8 | |g year:2023 |g day:28 |g month:09 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/74669201/publication/AU2022220252A1?q=AU2022220252 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 28 |c 09 | ||