Construction and application of vancomycin AUC calculator
The invention belongs to the technical field of medical artificial intelligence, and particularly relates to construction and application of a vancomycin AUC0-24h calculator. According to the method, a one-atrioventricular model is combined with a first-level dynamic formula, a calculation formula for calculating the blood concentration of an infusion section and an elimination section of a patient after multi-dose intravenous infusion vancomycin of the patient reaches a steady state is deduced, an AUC0-24h calculator is programmed by software, the blood concentration of the infusion section and the elimination section of the patient is fitted, a planning solving function in the software is utilized, and the accuracy of the multi-dose intravenous infusion vancomycin in the patient is improved. Linear fitting is carried out to calculate individual Ke and Vd of the patient, and the Ke and Vd are substituted into a formula to calculate AUC0-24h/MIC of the patient; the established vancomycin AUC0-24h/MIC calculator is good in prediction performance, and can provide reference for clinical individualized use of vancomycin..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 23. Juni Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HUANG QI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-06-23, Last update posted on www.tib.eu: 2023-11-28, Last updated: 2023-12-01 |
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| Patentnummer: |
CN116313152 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018098193 |
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| 520 | |a The invention belongs to the technical field of medical artificial intelligence, and particularly relates to construction and application of a vancomycin AUC0-24h calculator. According to the method, a one-atrioventricular model is combined with a first-level dynamic formula, a calculation formula for calculating the blood concentration of an infusion section and an elimination section of a patient after multi-dose intravenous infusion vancomycin of the patient reaches a steady state is deduced, an AUC0-24h calculator is programmed by software, the blood concentration of the infusion section and the elimination section of the patient is fitted, a planning solving function in the software is utilized, and the accuracy of the multi-dose intravenous infusion vancomycin in the patient is improved. Linear fitting is carried out to calculate individual Ke and Vd of the patient, and the Ke and Vd are substituted into a formula to calculate AUC0-24h/MIC of the patient; the established vancomycin AUC0-24h/MIC calculator is good in prediction performance, and can provide reference for clinical individualized use of vancomycin. | ||
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