Method for isolating neoantigen-specific T cell receptor sequences
Methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences or antigen-binding portions thereof are disclosed. Also disclosed are methods of automatically identifying TCR alpha and beta chain V segment sequences and CDR3 sequences of TCRs that have antigen specificity for mutated amino acid sequences encoded by cancer-specific mutations. Also disclosed are methods of making cell populations expressing paired TCR [alpha] and [beta] chain sequences or antigen-binding portions thereof. Isolated pairs of TCR [alpha] and [beta] chain sequences and isolated populations of cells prepared by the methods are also disclosed..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LU YONG-CHEN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-12, Last update posted on www.tib.eu: 2024-02-26, Last updated: 2024-03-01 |
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| Patentnummer: |
CN116726047 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA018028349 |
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| 520 | |a Methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences or antigen-binding portions thereof are disclosed. Also disclosed are methods of automatically identifying TCR alpha and beta chain V segment sequences and CDR3 sequences of TCRs that have antigen specificity for mutated amino acid sequences encoded by cancer-specific mutations. Also disclosed are methods of making cell populations expressing paired TCR [alpha] and [beta] chain sequences or antigen-binding portions thereof. Isolated pairs of TCR [alpha] and [beta] chain sequences and isolated populations of cells prepared by the methods are also disclosed. | ||
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