Preparation method of enteric-coated tablet containing mesalazine
The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of an enteric-coated tablet containing mesalazine. The enteric-coated tablet sequentially comprises a tablet core and an enteric-coated layer from inside to outside, the preparation method comprises the following steps: (1) mixing tablet core components, and preparing granules by adopting a dry granulation process; (2) tabletting the granules to obtain tablet cores; (3) wrapping the tablet core with an enteric-coated layer; in the dry granulation, the pressure of a compression roller is controlled to be about 10 bar to 70 bar, the rotating speed of the compression roller is controlled to be about 6 rpm to 20 rpm, the rotating speed of whole granules is controlled to be about 100 rpm to 150 rpm, and the aperture of a screen is controlled to be 0.6 mm to 2.0 mm; the hardness of the tablet core is controlled to be about 80 N to 150 N. According to the preparation method of the product, dry granulation is adopted on the basis of a selected prescription, the production efficiency is high, the product quality is stable, the cost is lower, and the product has a release curve basically consistent with that of an original ground medicine..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 21. Apr. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHU HONGGANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-04-21, Last update posted on www.tib.eu: 2023-09-19, Last updated: 2023-09-22 |
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| Patentnummer: |
CN115990141 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017972965 |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-04-21, Last update posted on www.tib.eu: 2023-09-19, Last updated: 2023-09-22 | ||
| 520 | |a The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of an enteric-coated tablet containing mesalazine. The enteric-coated tablet sequentially comprises a tablet core and an enteric-coated layer from inside to outside, the preparation method comprises the following steps: (1) mixing tablet core components, and preparing granules by adopting a dry granulation process; (2) tabletting the granules to obtain tablet cores; (3) wrapping the tablet core with an enteric-coated layer; in the dry granulation, the pressure of a compression roller is controlled to be about 10 bar to 70 bar, the rotating speed of the compression roller is controlled to be about 6 rpm to 20 rpm, the rotating speed of whole granules is controlled to be about 100 rpm to 150 rpm, and the aperture of a screen is controlled to be 0.6 mm to 2.0 mm; the hardness of the tablet core is controlled to be about 80 N to 150 N. According to the preparation method of the product, dry granulation is adopted on the basis of a selected prescription, the production efficiency is high, the product quality is stable, the cost is lower, and the product has a release curve basically consistent with that of an original ground medicine. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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