RATIONALLY DESIGNED SINGLE-ROUND INFECTIOUS VIRUS AND METHODS OF USE THEREOF
Provided are engineered, replication-deficient influenza viruses that are infectious and stimulate broadly-cross protective immunity against multiple different influenza strains. Also provided are compositions and methods for providing protective immune responses against influenza. The methods deliver compositions of intact, replication-deficient influenza viruses by intradermal administration in an amount effective to elicit or stimulate a cross-protective immune response to influenza viruses in the recipient following a single administration. Because the engineered influenza viruses are non-replicating, they are safe and effective in immunocompromised subjects. Also provided are methods for delivering co-stimulatory molecules, growth factors, adjuvants and/ or cytokines together with the non-replicating influenza viruses..
| Medienart: |
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 27. Juli Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
KOK KIN HANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-07-27, Last update posted on www.tib.eu: 2024-03-07, Last updated: 2024-03-08 |
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| Patentnummer: |
WO2023138651 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017795516 |
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| 520 | |a Provided are engineered, replication-deficient influenza viruses that are infectious and stimulate broadly-cross protective immunity against multiple different influenza strains. Also provided are compositions and methods for providing protective immune responses against influenza. The methods deliver compositions of intact, replication-deficient influenza viruses by intradermal administration in an amount effective to elicit or stimulate a cross-protective immune response to influenza viruses in the recipient following a single administration. Because the engineered influenza viruses are non-replicating, they are safe and effective in immunocompromised subjects. Also provided are methods for delivering co-stimulatory molecules, growth factors, adjuvants and/ or cytokines together with the non-replicating influenza viruses. | ||
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