PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING MELANOMA COMPRISING K-RAS-SPECIFIC ACTIVATED T CELLS, AND METHOD FOR PREPARING SAME
A pharmaceutical composition for preventing and treating melanoma comprising K-ras-specific activated T cells according to the present invention is an antigen composition wherein K-ras mutant (G12D, G12V, and G13D) recombinant overlapping peptides are sequentially divided into a total of 12 epitopes (n=1 to 12, with the proviso that the last epitope (n=12) is 23 amino acids) of 30 amino acids in the amino acid sequence of K-ras, and is designed so that 15 amino acid sequences overlap between the epitopes, and thus the pharmaceutical composition has the advantage of being more effective in recognizing and killing melanoma in which the K-ras, the K-ras mutant G12V, the K-ras mutant G12D, or the K-ras mutant G13D is detected. Therefore, the pharmaceutical composition for preventing and treating melanoma comprising K-ras-specific activated T cells according to the present invention has the advantage that the pharmaceutical composition can be used to effectively prevent and treat melanoma in which K-ras as well as K-ras mutants are detected..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 06. Juli Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LEE WANG JUN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-07-06, Last update posted on www.tib.eu: 2023-08-08, Last updated: 2023-08-11 |
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| Patentnummer: |
WO2023128381 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017656966 |
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| 245 | 1 | 0 | |a PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING MELANOMA COMPRISING K-RAS-SPECIFIC ACTIVATED T CELLS, AND METHOD FOR PREPARING SAME |
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| 520 | |a A pharmaceutical composition for preventing and treating melanoma comprising K-ras-specific activated T cells according to the present invention is an antigen composition wherein K-ras mutant (G12D, G12V, and G13D) recombinant overlapping peptides are sequentially divided into a total of 12 epitopes (n=1 to 12, with the proviso that the last epitope (n=12) is 23 amino acids) of 30 amino acids in the amino acid sequence of K-ras, and is designed so that 15 amino acid sequences overlap between the epitopes, and thus the pharmaceutical composition has the advantage of being more effective in recognizing and killing melanoma in which the K-ras, the K-ras mutant G12V, the K-ras mutant G12D, or the K-ras mutant G13D is detected. Therefore, the pharmaceutical composition for preventing and treating melanoma comprising K-ras-specific activated T cells according to the present invention has the advantage that the pharmaceutical composition can be used to effectively prevent and treat melanoma in which K-ras as well as K-ras mutants are detected. | ||
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| 650 | 4 | |a che | |
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