NOVEL FLT3 ANTIBODIES AND ANTIBODY-DRUG-CONJUGATES BASED THEREON, THERAPEUTIC METHODS AND USES THEREOF IN COMBINATION WITH TYROSINE KINASE INHIBITORS
The present invention relates to novel anti-FLT3 antibodies for specifically targeting extracellular domain of FLT3. The present invention further relates to targeting FLT3 by novel antibody-drug- conjugates (ADCs) based on the novel anti-FLT3 antibodies of the present invention, especially in combination with kinase inhibitors, for use in therapy and/or for use in a method of cancer treatment (e.g., acute myeloid leukemia (AML) with or without internal tandem duplication (ITD) mutations in the FLT3 gene (FLT3-ITD))..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Juni Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
LEONHARDT HEINRICH [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-06-15, Last update posted on www.tib.eu: 2023-11-17, Last updated: 2023-11-24 |
|---|
| Patentnummer: |
WO2023105087 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA017512247 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA017512247 | ||
| 003 | DE-627 | ||
| 005 | 20231124095836.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230708s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA017512247 | ||
| 035 | |a (EPA)WO2023105087 | ||
| 035 | |a (EPA)78829618 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a LEONHARDT HEINRICH |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a NOVEL FLT3 ANTIBODIES AND ANTIBODY-DRUG-CONJUGATES BASED THEREON, THERAPEUTIC METHODS AND USES THEREOF IN COMBINATION WITH TYROSINE KINASE INHIBITORS |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-06-15, Last update posted on www.tib.eu: 2023-11-17, Last updated: 2023-11-24 | ||
| 520 | |a The present invention relates to novel anti-FLT3 antibodies for specifically targeting extracellular domain of FLT3. The present invention further relates to targeting FLT3 by novel antibody-drug- conjugates (ADCs) based on the novel anti-FLT3 antibodies of the present invention, especially in combination with kinase inhibitors, for use in therapy and/or for use in a method of cancer treatment (e.g., acute myeloid leukemia (AML) with or without internal tandem duplication (ITD) mutations in the FLT3 gene (FLT3-ITD)). | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
| 650 | 4 | |a che | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a STENGL ANDREAS |4 aut | |
| 700 | 0 | |a ROAS MAIKE |4 aut | |
| 700 | 0 | |a SCHWACH JONATHAN |4 aut | |
| 700 | 0 | |a SPIEKERMANN KARSTEN |4 aut | |
| 700 | 0 | |a POLZER HARALD |4 aut | |
| 700 | 0 | |a ABLE MARINA |4 aut | |
| 700 | 0 | |a HELMA-SMETS JONAS |4 aut | |
| 700 | 0 | |a SCHUMACHER DOMINIK |4 aut | |
| 700 | 0 | |a GERLACH MARCUS |4 aut | |
| 700 | 0 | |a HACKENBERGER CHRISTIAN PETER RICHARD |4 aut | |
| 700 | 0 | |a KASPER MARC-ANDRÉ |4 aut | |
| 700 | 0 | |a JEREMIAS IRMELA |4 aut | |
| 700 | 0 | |a VICK BINJE |4 aut | |
| 700 | 0 | |a KREMMER ELISABETH |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 15. Juni |
| 773 | 1 | 8 | |g year:2023 |g day:15 |g month:06 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/78829618/publication/WO2023105087A1?q=WO2023105087 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 936 | u | w | |j 2023 |b 15 |c 06 |
| 951 | |a AR | ||
| 952 | |j 2023 |b 15 |c 06 | ||