Compounds for imaging tau proteins that accumulate in brain
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof:wherein:R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;R3 is hydrogen or halogen;ring A is a benzene ring or a pyridine ring;ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv):in the formula (ii), Ra is alkyl;R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; andrepresents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 06. Juni Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HIGUCHI MAKOTO [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-06-06, Last update posted on www.tib.eu: 2023-07-05, Last updated: 2023-07-14 |
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| Patentnummer: |
US11667628 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA01750256X |
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| 245 | 1 | 0 | |a Compounds for imaging tau proteins that accumulate in brain |
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| 520 | |a The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof:wherein:R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;R3 is hydrogen or halogen;ring A is a benzene ring or a pyridine ring;ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv):in the formula (ii), Ra is alkyl;R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; andrepresents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain. | ||
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