Tumor anti-PD-L1 monoclonal antibody targeting TGF-beta1-siRNA nanoparticles and preparation method thereof
The invention provides a tumor anti-PD-L1 monoclonal antibody targeting TGF (Transforming Growth Factor)-beta 1-siRNA (Small Interference Ribonucleic Acid) nano particle and a preparation method thereof. The nano particle is formed by connecting a PD-L1 monoclonal antibody, polyethylene glycol and polycaprolactone to form a tumor anti-PD-L1 monoclonal antibody targeting drug-loading polymer PDL1-PEG-PCL and then physically wrapping TGF-beta 1-siRNA. The tumor anti-PD-L1 monoclonal antibody targeted TGF-beta1-siRNA nano particle is good in targeting property and small in toxic and side effects, and the preparation method of the tumor anti-PD-L1 monoclonal antibody targeted TGF-beta1-siRNA nano particle is simple in process, high in yield and few in side reaction..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 31. März Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WU FENGLEI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-03-31, Last update posted on www.tib.eu: 2023-06-21, Last updated: 2023-06-30 |
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| Patentnummer: |
CN115869424 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017324017 |
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| 520 | |a The invention provides a tumor anti-PD-L1 monoclonal antibody targeting TGF (Transforming Growth Factor)-beta 1-siRNA (Small Interference Ribonucleic Acid) nano particle and a preparation method thereof. The nano particle is formed by connecting a PD-L1 monoclonal antibody, polyethylene glycol and polycaprolactone to form a tumor anti-PD-L1 monoclonal antibody targeting drug-loading polymer PDL1-PEG-PCL and then physically wrapping TGF-beta 1-siRNA. The tumor anti-PD-L1 monoclonal antibody targeted TGF-beta1-siRNA nano particle is good in targeting property and small in toxic and side effects, and the preparation method of the tumor anti-PD-L1 monoclonal antibody targeted TGF-beta1-siRNA nano particle is simple in process, high in yield and few in side reaction. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
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