KAPPA OPIOD RECEPTOR ANTAGONISTS FOR TREATING PAIN-RELATED SLEEP DISORDERS
Chronic pain patients complain about sleep disturbance with a high probability, while sleep loss increases pain in chronic pain patients. Sleep problems and pain promote a vicious spiral, suggesting a need for simultaneous treatment of both. The present invention provides a method to treat pain-related sleep disorders through distribution of a therapeutic amount of a KOR antagonist. The use of KOR antagonist could be a novel therapeutic agent for sleep disturbance in chronic pain patients. Additionally, KOR antagonists could be used to improve sleep in other conditions, such as depression or general anxiety disorder, where KOR signaling is induced..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 11. Mai Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
PORRECA FRANK [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-05-11, Last update posted on www.tib.eu: 2023-06-22, Last updated: 2023-06-30 |
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| Patentnummer: |
US2023146937 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017267870 |
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| 520 | |a Chronic pain patients complain about sleep disturbance with a high probability, while sleep loss increases pain in chronic pain patients. Sleep problems and pain promote a vicious spiral, suggesting a need for simultaneous treatment of both. The present invention provides a method to treat pain-related sleep disorders through distribution of a therapeutic amount of a KOR antagonist. The use of KOR antagonist could be a novel therapeutic agent for sleep disturbance in chronic pain patients. Additionally, KOR antagonists could be used to improve sleep in other conditions, such as depression or general anxiety disorder, where KOR signaling is induced. | ||
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