Application of aescin IA in preparation of anti-SARS-CoV-2 medicine
The invention discloses application of aescin IA in preparation of anti-SARS-CoV-2 drugs, and belongs to the technical field of preparation of antiviral drugs. According to the present invention, the drug is subjected to SARS-CoV-2-Sh/CMC model analysis, and the drug is subjected to molecular docking with the SARS-CoV-2 S protein and the cell TMPRSS2 enzyme, such that the binding specificity of the aescin IA, the SARS-CoV-2 S protein and the cell TMPRSS2 enzyme is determined; the SARS-CoV-2 pseudovirus is utilized to infect ACE2 high-expression cells and ACE2/TMPRSS2 common high-expression cells, and it is proved that the drug has the characteristic of double targets. According to the technology, the aescin IA has the effect of the medicine for resisting SARS-CoV-2 pneumonia, and can be used for preparing the medicine for resisting SARS-CoV-2 pneumonia..
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 23. Sept. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HE LANGCHONG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-09-23, Last update posted on www.tib.eu: 2023-06-21, Last updated: 2023-06-30 |
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| Patentnummer: |
CN115089597 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017228654 |
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| 520 | |a The invention discloses application of aescin IA in preparation of anti-SARS-CoV-2 drugs, and belongs to the technical field of preparation of antiviral drugs. According to the present invention, the drug is subjected to SARS-CoV-2-Sh/CMC model analysis, and the drug is subjected to molecular docking with the SARS-CoV-2 S protein and the cell TMPRSS2 enzyme, such that the binding specificity of the aescin IA, the SARS-CoV-2 S protein and the cell TMPRSS2 enzyme is determined; the SARS-CoV-2 pseudovirus is utilized to infect ACE2 high-expression cells and ACE2/TMPRSS2 common high-expression cells, and it is proved that the drug has the characteristic of double targets. According to the technology, the aescin IA has the effect of the medicine for resisting SARS-CoV-2 pneumonia, and can be used for preparing the medicine for resisting SARS-CoV-2 pneumonia. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
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