IMMUNOSTIMULATORY COMPOSITIONS
The invention relates to an immunostimulatory composition comprising a liposome-nucleic acid complex wherein said complex contains (1) a liposome which, in terms of its lipids, comprises or consists of a first lipid and a second lipid, wherein the first lipid is a zwitterionic lipid and the second lipid is a cationic lipid, and (2) one or more immunostimulatory oligonucleotides and/or one or more polynucleotides. The invention further relates to certain uses of the immunostimulatory composition and to methods for preparing the same. In particular, the invention concerns the use of a zwitterionic lipid in an immunostimulatory composition comprising a liposome-nucleic acid complex to induce type I interferon immune responses and/or to reduce or even bypass TLR-mediated immune responses..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 29. März Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
PUTZKE SIMONE MARLENE [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-03-29, Last update posted on www.tib.eu: 2024-01-30, Last updated: 2024-02-02 |
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| Patentnummer: |
EP4153129 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA017080975 |
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| 520 | |a The invention relates to an immunostimulatory composition comprising a liposome-nucleic acid complex wherein said complex contains (1) a liposome which, in terms of its lipids, comprises or consists of a first lipid and a second lipid, wherein the first lipid is a zwitterionic lipid and the second lipid is a cationic lipid, and (2) one or more immunostimulatory oligonucleotides and/or one or more polynucleotides. The invention further relates to certain uses of the immunostimulatory composition and to methods for preparing the same. In particular, the invention concerns the use of a zwitterionic lipid in an immunostimulatory composition comprising a liposome-nucleic acid complex to induce type I interferon immune responses and/or to reduce or even bypass TLR-mediated immune responses. | ||
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