RECOMBINANT REELIN GENE THERAPY
The disclosure describes novel Reelin repeat fusion proteins for use as a therapeutic in the treatment of a disease or disorder of the nervous system. Intracerebroventricular administration of AAV vectors expressing a Reelin repeat fusion protein is shown to rescue impairment of spine density in the hippocampus of reeler and attenuate hyperactivity of FMR-/- knockout mice in an open field assay..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 07. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WEEBER EDWIN J [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-09-07, Last update posted on www.tib.eu: 2023-10-16, Last updated: 2023-10-20 |
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| Patentnummer: |
WO2023288325 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA016460588 |
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| 520 | |a The disclosure describes novel Reelin repeat fusion proteins for use as a therapeutic in the treatment of a disease or disorder of the nervous system. Intracerebroventricular administration of AAV vectors expressing a Reelin repeat fusion protein is shown to rescue impairment of spine density in the hippocampus of reeler and attenuate hyperactivity of FMR-/- knockout mice in an open field assay. | ||
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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