Preparation method and application of biphase drug-loaded gel bead
The invention relates to a preparation method and application of biphase drug-loaded gel bead, and belongs to the field of biomedical materials. The biphase drug-loaded gel bead comprise an inner-phase drug-loaded gel bead and an outer-phase hydrogel layer, sodium alginate, k-carrageenan and a drug are cross-linked through a cross-linking agent to prepare the inner-phase drug-loaded gel bead, and then the inner-phase drug-loaded gel bead is wrapped by a polyelectrolyte shell composed of k-CG and epsilon-PL to obtain the biphase drug-loaded gel bead. The drug loading performance of the inner phase of the prepared biphase drug-loading gel bead is improved through process optimization, the drug can be protected from being degraded by gastric acid and pepsin after the outer phase is wrapped, the biphase drug-loading gel bead can be slowly released in the intestinal tract to achieve the effect of reducing blood sugar, and the biphase drug-loading gel bead can be used for all drugs which are not resistant to the gastric acid and absorbed by the intestinal tract..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 23. Nov. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG WANNENG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-11-23, Last update posted on www.tib.eu: 2022-11-24, Last updated: 2023-02-09 |
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| Patentnummer: |
CN113679842 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA016070887 |
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| 520 | |a The invention relates to a preparation method and application of biphase drug-loaded gel bead, and belongs to the field of biomedical materials. The biphase drug-loaded gel bead comprise an inner-phase drug-loaded gel bead and an outer-phase hydrogel layer, sodium alginate, k-carrageenan and a drug are cross-linked through a cross-linking agent to prepare the inner-phase drug-loaded gel bead, and then the inner-phase drug-loaded gel bead is wrapped by a polyelectrolyte shell composed of k-CG and epsilon-PL to obtain the biphase drug-loaded gel bead. The drug loading performance of the inner phase of the prepared biphase drug-loading gel bead is improved through process optimization, the drug can be protected from being degraded by gastric acid and pepsin after the outer phase is wrapped, the biphase drug-loading gel bead can be slowly released in the intestinal tract to achieve the effect of reducing blood sugar, and the biphase drug-loading gel bead can be used for all drugs which are not resistant to the gastric acid and absorbed by the intestinal tract. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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