LPXH INHIBITORS AS ANTI-INFECTIVE AGENTS
The present invention relates to compounds of formula (IIIa), which are suitable for use as anti-infectives, particularly as antibiotics. X1 is N or CH. …. is a single or a double bond. When …. is a single bond then X2 is selected from the group consisting of CH, N, and N(O), and Y is selected from the group consisting of optionally substituted C3-C10 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted phenyl, and optionally substituted 6-membered heteroaryl. When …. is a double bond then X2 is C, and, and Y is selected from the group consisting of optionally substituted C3-C10 alkylidene, and optionally substituted C3-C8 cycloalkylidene. E is CH, C-OMe or N. Each instance of Z2 is independently selected from CH, CF and N. The invention further relates to the use of such compounds in therapeutic applications, as well as pharmaceutical composition comprising such compounds..
| Medienart: |
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 20. Okt. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZAMARATSKI EDOUARD [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-10-20, Last update posted on www.tib.eu: 2022-11-23, Last updated: 2023-02-09 |
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| Patentnummer: |
WO2022220725 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA016058224 |
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| 520 | |a The present invention relates to compounds of formula (IIIa), which are suitable for use as anti-infectives, particularly as antibiotics. X1 is N or CH. …. is a single or a double bond. When …. is a single bond then X2 is selected from the group consisting of CH, N, and N(O), and Y is selected from the group consisting of optionally substituted C3-C10 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted phenyl, and optionally substituted 6-membered heteroaryl. When …. is a double bond then X2 is C, and, and Y is selected from the group consisting of optionally substituted C3-C10 alkylidene, and optionally substituted C3-C8 cycloalkylidene. E is CH, C-OMe or N. Each instance of Z2 is independently selected from CH, CF and N. The invention further relates to the use of such compounds in therapeutic applications, as well as pharmaceutical composition comprising such compounds. | ||
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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