Polymer micro-robot as well as preparation method and application thereof
The invention provides a polymer micro-robot as well as a preparation method and application thereof. The preparation method comprises the following steps of (1) dissolving an oil-soluble polymer, an oil-soluble anti-tumor drug and oleic acid coated magnetic iron nanoparticles in an organic solvent, mixing, then adding the mixed solution into a precursor aqueous solution, stirring, centrifuging, washing, and obtaining magnetic polymer particles loaded with the anti-tumor drugs; (2) adding the magnetic polymer particles loaded with the anti-tumor drug into the precursor aqueous solution, then adding glycerol, mixing, and carrying out forced air drying to obtain a hydrogel film; and (3) heating the hydrogel film, stretching the film, and dissolving the stretched film in an aqueous solution to obtain the polymer micro-robot. The polymer micro-robot prepared by the invention is good in biocompatibility, can load anti-tumor drugs, and can realize targeted transportation of the drugs under the control of a magnetic field..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 28. Sept. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHENG YUJI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-09-28, Last update posted on www.tib.eu: 2022-11-22, Last updated: 2023-02-09 |
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| Patentnummer: |
CN113440472 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA015874206 |
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| 520 | |a The invention provides a polymer micro-robot as well as a preparation method and application thereof. The preparation method comprises the following steps of (1) dissolving an oil-soluble polymer, an oil-soluble anti-tumor drug and oleic acid coated magnetic iron nanoparticles in an organic solvent, mixing, then adding the mixed solution into a precursor aqueous solution, stirring, centrifuging, washing, and obtaining magnetic polymer particles loaded with the anti-tumor drugs; (2) adding the magnetic polymer particles loaded with the anti-tumor drug into the precursor aqueous solution, then adding glycerol, mixing, and carrying out forced air drying to obtain a hydrogel film; and (3) heating the hydrogel film, stretching the film, and dissolving the stretched film in an aqueous solution to obtain the polymer micro-robot. The polymer micro-robot prepared by the invention is good in biocompatibility, can load anti-tumor drugs, and can realize targeted transportation of the drugs under the control of a magnetic field. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a B25J: Manipulators; chambers provided with manipulation devices (robotic devices for individually picking fruits, vegetables, hops or the like a01d0046300000;needle manipulators for surgery a61b0017062000;manipulators associated with rolling mills b21b0039200000;manipulators associated with forging machines b21j0013100000;means for holding wheels or parts thereof b60b0030000000;cranes b66c;arrangements for handling fuel or other materials which are used within nuclear reactors g21c0019000000;structural combination of manipulators with cells or rooms shielded against radiation g21f0007060000) | |
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