Thrombin-binding antibody molecules and uses thereof

This invention relates to isolated antibodies which recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin..

Medienart:

Patent

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Europäisches Patentamt - (2021) vom: 26. Okt. Zur Gesamtaufnahme - year:2021

Sprache:

Englisch

Beteiligte Personen:

HUNTINGTON JAMES ANDREW [VerfasserIn]
BAGLIN TREVOR [VerfasserIn]
LANGDOWN JONATHAN [VerfasserIn]

Links:

Volltext [kostenfrei]

Themen:

615
A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d)
C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000)
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Anmerkungen:

Source: www.epo.org (no modifications made), First posted: 2021-10-26, Last update posted on www.tib.eu: 2022-11-12, Last updated: 2023-02-09

Patentnummer:

US11155637

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

EPA015564037