ANTI-ALPHA-HEMOLYSIN ANTIBODY AND USE THEREOF
Provided are an antibody that binds to Staphylococcus aureus alpha-hemolysin or a fragment thereof, and the use of the antibody or the fragment thereof for preventing or treating Staphylococcus aureus infections. The antibody is obtained through screening by means of the strategies of attenuated immunity and virulent screening of alpha-hemolysin, and the antibody has high affinity to alpha-hemolysin, can effectively block the hemolysis effect of alpha-hemolysin, has proved significant protective or therapeutic effects in the alpha-hemolysin sepsis model, MRSA bacteremia model and MRSA lung infection model, and has a synergistic effect with antibiotics, which is a beneficial supplement to existing antibiotic therapy for Staphylococcus aureus..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Europäisches Patentamt - (2024) vom: 24. Jan. Zur Gesamtaufnahme - year:2024 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
AN MAOMAO [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-24, Last update posted on www.tib.eu: 2024-02-06, Last updated: 2024-02-09 |
---|
Patentnummer: |
EP4032904 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA015508676 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA015508676 | ||
003 | DE-627 | ||
005 | 20240209083704.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230216s2024 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)EPA015508676 | ||
035 | |a (EPA)EP4032904 | ||
035 | |a (EPA)74883889 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a AN MAOMAO |e verfasserin |4 aut | |
245 | 1 | 0 | |a ANTI-ALPHA-HEMOLYSIN ANTIBODY AND USE THEREOF |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), First posted: 2024-01-24, Last update posted on www.tib.eu: 2024-02-06, Last updated: 2024-02-09 | ||
520 | |a Provided are an antibody that binds to Staphylococcus aureus alpha-hemolysin or a fragment thereof, and the use of the antibody or the fragment thereof for preventing or treating Staphylococcus aureus infections. The antibody is obtained through screening by means of the strategies of attenuated immunity and virulent screening of alpha-hemolysin, and the antibody has high affinity to alpha-hemolysin, can effectively block the hemolysis effect of alpha-hemolysin, has proved significant protective or therapeutic effects in the alpha-hemolysin sepsis model, MRSA bacteremia model and MRSA lung infection model, and has a synergistic effect with antibiotics, which is a beneficial supplement to existing antibiotic therapy for Staphylococcus aureus. | ||
650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
650 | 4 | |a che | |
650 | 4 | |a 615 | |
700 | 0 | |a WANG LICHUN |4 aut | |
700 | 0 | |a GAO PAN |4 aut | |
700 | 0 | |a LIN JIAN |4 aut | |
700 | 0 | |a JIANG YUANYING |4 aut | |
700 | 0 | |a SHEN HUI |4 aut | |
700 | 0 | |a CHEN SIMIN |4 aut | |
700 | 0 | |a GUO SHIYU |4 aut | |
700 | 0 | |a FANG WEI |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2024) vom: 24. Jan. |
773 | 1 | 8 | |g year:2024 |g day:24 |g month:01 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/74883889/publication/EP4032904A1?q=EP4032904 |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
936 | u | w | |j 2024 |b 24 |c 01 |
951 | |a AR | ||
952 | |j 2024 |b 24 |c 01 |