METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY CONDITIONS
The present invention provides novel compositions for suppressing inflammation and for treating inflammatory disorders. These compositions contain at least one PARS-derived anti-inflammatory peptide or polypeptide and/or at least one PARI-derived anti-inflammatory peptide or polypeptide. The PARS- and/or PARI-derived peptides typically contain an amino acid sequence that mimics the respective N-terminal sequence of Activated Protein C-cleaved PARS or PARI, e.g., after activated protein C cleavage at residue Arg41 in human PARS and after residue Arg46 in human PARI. The invention also provides therapeutic methods of using the anti-inflammatory compositions described herein to suppress undesired inflammation and to treat inflammatory disorders. Additionally provided in the invention are methods of screening candidate compounds to identity novel anti-inflammatory agents..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 18. Okt. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HEALY LAURA D [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-10-18, Last update posted on www.tib.eu: 2023-10-31, Last updated: 2023-11-03 |
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| Patentnummer: |
EP3986560 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA015351734 |
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| 520 | |a The present invention provides novel compositions for suppressing inflammation and for treating inflammatory disorders. These compositions contain at least one PARS-derived anti-inflammatory peptide or polypeptide and/or at least one PARI-derived anti-inflammatory peptide or polypeptide. The PARS- and/or PARI-derived peptides typically contain an amino acid sequence that mimics the respective N-terminal sequence of Activated Protein C-cleaved PARS or PARI, e.g., after activated protein C cleavage at residue Arg41 in human PARS and after residue Arg46 in human PARI. The invention also provides therapeutic methods of using the anti-inflammatory compositions described herein to suppress undesired inflammation and to treat inflammatory disorders. Additionally provided in the invention are methods of screening candidate compounds to identity novel anti-inflammatory agents. | ||
| 650 | 4 | |a tec | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a G01N: Investigating or analysing materials by determining their chemical or physical properties (measuring or testing processes other than immunoassay, involving enzymes or microorganisms c12m, c12q) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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