NOVEL HUMAN INTERLEUKIN-18 VARIANT AND USE THEREFOR
The present invention pertains to a novel interleukin-18 (IL-18) variant and a pharmaceutical composition using the same. Specifically, the present invention pertains to a human IL-18 variant that includes, in the amino acid sequence of wild-type human IL-18, (i) a mutation of the cysteine at positions 38, 68, 76, and 127 into serine, and (ii) a mutation of the glutamic acid at position 6 and the lysine at position 53 into alanine, said human IL-18 variant including (iii) at least 1 additional mutation. The present invention also pertains to a pharmaceutical composition including said human IL-18 variant..
| Medienart: |
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 18. Aug. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
TANAKA YOSHIMASA [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-08-18, Last update posted on www.tib.eu: 2024-02-06, Last updated: 2024-02-09 |
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| Patentnummer: |
WO2022172944 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA015017265 |
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| 520 | |a The present invention pertains to a novel interleukin-18 (IL-18) variant and a pharmaceutical composition using the same. Specifically, the present invention pertains to a human IL-18 variant that includes, in the amino acid sequence of wild-type human IL-18, (i) a mutation of the cysteine at positions 38, 68, 76, and 127 into serine, and (ii) a mutation of the glutamic acid at position 6 and the lysine at position 53 into alanine, said human IL-18 variant including (iii) at least 1 additional mutation. The present invention also pertains to a pharmaceutical composition including said human IL-18 variant. | ||
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