Pharmaceutical compositions comprising thrombolytic peptide-tetrahydroisoquinoline conjugates
The present invention provides a pharmaceutical composition comprising a binary conjugate DC009 and a pharmaceutically acceptable carrier, and the DC009 is a conjugate obtained by conjugating a thrombolytic peptide (Pro-Ala-Lys) and a tetrahydroisoquinoline compound having two C1-4 alkyl groups through a lysine linking arm. The composition has a pH of less than 6.5, preferably a pH of from about pH 2 to 5.5. The composition may comprise a pharmaceutically acceptable excipient such as mannitol, sorbitol, sucrose, lactose or trehalose..
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 27. Mai Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHOU ZHIGUANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-05-27, Last update posted on www.tib.eu: 2024-02-05, Last updated: 2024-02-09 |
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| Patentnummer: |
CN114555085 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA014671905 |
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| 245 | 1 | 0 | |a Pharmaceutical compositions comprising thrombolytic peptide-tetrahydroisoquinoline conjugates |
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| 520 | |a The present invention provides a pharmaceutical composition comprising a binary conjugate DC009 and a pharmaceutically acceptable carrier, and the DC009 is a conjugate obtained by conjugating a thrombolytic peptide (Pro-Ala-Lys) and a tetrahydroisoquinoline compound having two C1-4 alkyl groups through a lysine linking arm. The composition has a pH of less than 6.5, preferably a pH of from about pH 2 to 5.5. The composition may comprise a pharmaceutically acceptable excipient such as mannitol, sorbitol, sucrose, lactose or trehalose. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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