Method for preparing three-axis concentric nanofiber based on controllable drug release
The invention discloses a method for preparing three-axis concentric nanofiber based on controllable drug release, and belongs to the technical field of functional textiles. The preparation method comprises the following steps of dissolving polycaprolactone in trichloromethane, dropwise adding sorbitan monooleate, stirring to obtain an oil phase, dissolving tetracycline hydrochloride in deionized water to obtain a tetracycline hydrochloride aqueous solution, weighing the tetracycline hydrochloride aqueous solution, gradually dropwise adding the tetracycline hydrochloride aqueous solution into the oil phase, forming an emulsion under the condition of stirring with an ultrasonic probe to serve as a core layer spinning solution, dissolving polyvinylpyrrolidone into N,N-dimethylformamide to obtain a uniform bubble-free shell layer spinning solution, connecting the core layer spinning solution with an inner cavity of a coaxial spinning nozzle, connecting the shell layer spinning solution with an outer cavity of the coaxial spinning nozzle, and performing electrostatic spinning through spraying of the coaxial spinning nozzle. The three-axis concentric nanofiber is prepared by combining emulsion electrostatic spinning with coaxial electrostatic spinning, the operation is simple, the reaction condition is mild, and the use efficiency of drugs can be improved through a multistage drug sustained-release system..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 02. Juli Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LIU YI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-07-02, Last update posted on www.tib.eu: 2022-10-22, Last updated: 2023-02-09 |
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| Patentnummer: |
CN113062011 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA014657058 |
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| 245 | 1 | 0 | |a Method for preparing three-axis concentric nanofiber based on controllable drug release |
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| 520 | |a The invention discloses a method for preparing three-axis concentric nanofiber based on controllable drug release, and belongs to the technical field of functional textiles. The preparation method comprises the following steps of dissolving polycaprolactone in trichloromethane, dropwise adding sorbitan monooleate, stirring to obtain an oil phase, dissolving tetracycline hydrochloride in deionized water to obtain a tetracycline hydrochloride aqueous solution, weighing the tetracycline hydrochloride aqueous solution, gradually dropwise adding the tetracycline hydrochloride aqueous solution into the oil phase, forming an emulsion under the condition of stirring with an ultrasonic probe to serve as a core layer spinning solution, dissolving polyvinylpyrrolidone into N,N-dimethylformamide to obtain a uniform bubble-free shell layer spinning solution, connecting the core layer spinning solution with an inner cavity of a coaxial spinning nozzle, connecting the shell layer spinning solution with an outer cavity of the coaxial spinning nozzle, and performing electrostatic spinning through spraying of the coaxial spinning nozzle. The three-axis concentric nanofiber is prepared by combining emulsion electrostatic spinning with coaxial electrostatic spinning, the operation is simple, the reaction condition is mild, and the use efficiency of drugs can be improved through a multistage drug sustained-release system. | ||
| 650 | 4 | |a cet | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a B82Y: Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | |
| 650 | 4 | |a D01D: Mechanical methods or apparatus in the manufacture of man-made filaments, threads, fibres, bristles or ribbons (working or processing of metal wire b21f;fibres or filaments of softened glass, minerals or slag c03b0037000000) | |
| 650 | 4 | |a D01F: Chemical features in the manufacture of man-made filaments, threads, fibres, bristles or ribbons; apparatus specially adapted for the manufacture of carbon filaments | |
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