Method for simultaneously inducing immune response against multiple viruses
The present application relates to methods of simultaneously inducing an immune response against a variety of viruses, such as influenza virus and new coronavirus. In particular, the present application provides an immunogenic peptide comprising (a) an immunogenic stem: comprising a HA2 region of influenza virus hemagglutinin HA; (b) an immunogenic crown: comprising a viral membrane protein or an immunogenic fragment thereof, wherein the source virus of the viral membrane protein is different from the source virus of the HA2 region in (a); and (c) optionally, other moieties fused with the foregoing moieties. The vaccine is safe, can continuously generate high-titer neutralizing antibodies and T cell responses, and can be used for preventing and treating influenza and new coronavirus..
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 22. März Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
XU JIANQING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-03-22, Last update posted on www.tib.eu: 2023-11-14, Last updated: 2023-11-17 |
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| Patentnummer: |
CN114213548 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA013858009 |
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| 520 | |a The present application relates to methods of simultaneously inducing an immune response against a variety of viruses, such as influenza virus and new coronavirus. In particular, the present application provides an immunogenic peptide comprising (a) an immunogenic stem: comprising a HA2 region of influenza virus hemagglutinin HA; (b) an immunogenic crown: comprising a viral membrane protein or an immunogenic fragment thereof, wherein the source virus of the viral membrane protein is different from the source virus of the HA2 region in (a); and (c) optionally, other moieties fused with the foregoing moieties. The vaccine is safe, can continuously generate high-titer neutralizing antibodies and T cell responses, and can be used for preventing and treating influenza and new coronavirus. | ||
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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