Small-molecular boron drug and application thereof
The invention discloses a small-molecular boron drug. The small-molecular boron drug has a structure as shown in a formula I that is described in the specification. In the formula I, R is any one selected from the group consisting of ortho-carborane, meta-carborane and para-carborane; and n is any integer selected from a range of 1 to 5. The boron drug can be transferred into cells through an amino acid transporter LAT1, a boron content in tumor cells is increased, and the boron drug can be traced and quantified by PET through fluorine-18 labeling. The prepared boron drug is simple in structure, high in boron content, easy to mark with fluorine-18 and then traced and quantified with PET, low in toxicity and capable of achieving the effect that the ratio of the boron content in animal tumor tissue to the boron content in blood is larger than 3.5..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 23. Juli Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
YU JIAHUI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-07-23, Last update posted on www.tib.eu: 2022-09-17, Last updated: 2023-02-09 |
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| Patentnummer: |
CN113150020 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA013631322 |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2021-07-23, Last update posted on www.tib.eu: 2022-09-17, Last updated: 2023-02-09 | ||
| 520 | |a The invention discloses a small-molecular boron drug. The small-molecular boron drug has a structure as shown in a formula I that is described in the specification. In the formula I, R is any one selected from the group consisting of ortho-carborane, meta-carborane and para-carborane; and n is any integer selected from a range of 1 to 5. The boron drug can be transferred into cells through an amino acid transporter LAT1, a boron content in tumor cells is increased, and the boron drug can be traced and quantified by PET through fluorine-18 labeling. The prepared boron drug is simple in structure, high in boron content, easy to mark with fluorine-18 and then traced and quantified with PET, low in toxicity and capable of achieving the effect that the ratio of the boron content in animal tumor tissue to the boron content in blood is larger than 3.5. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a C07F: Acyclic, carbocyclic, or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium (metal-containing porphyrins c07d0487220000;macromolecular compounds c08) | |
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