Application of tetrahydropalmatine in preparation of coronavirus infection resisting medicine
The invention discloses application of tetrahydropalmatine in preparation of a coronavirus infection resisting medicine, and belongs to the technical field of medicine. According to the application disclosed by the invention, the tetrahydropalmatine is found to be capable of inhibiting the replication of the pathogenic coronaviruses HCoV-OC43 and HCoV-229E on Huh-7 cells, and the median effective inhibitory concentration (EC50) values of the tetrahydropalmatine are 8.87 [mu]M and 28.80 [mu]M respectively. Meanwhile, the tetrahydropalmatine can effectively reduce the virus titers of HCoV-OC43 and HCoV-229E in Huh-7 cells, the virus inhibition rates are 92.16% and 93.79% respectively after 72 hours of administration under the condition that the maximum administration dosage is 60 [mu]M, and the tetrahydropalmatine has important application prospects in the aspect of clinical treatment or prevention of coronavirus infection..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 18. Feb. Zur Gesamtaufnahme - year:2022 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
CHEN JIANXIN [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Sonstige Themen: |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-02-18, Last update posted on www.tib.eu: 2023-06-02, Last updated: 2023-06-06 |
|---|
| Patentnummer: |
CN114053273 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA013481487 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA013481487 | ||
| 003 | DE-627 | ||
| 005 | 20230607081847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230215s2022 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA013481487 | ||
| 035 | |a (EPA)CN114053273 | ||
| 035 | |a (EPA)80271808 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a CHEN JIANXIN |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Application of tetrahydropalmatine in preparation of coronavirus infection resisting medicine |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2022-02-18, Last update posted on www.tib.eu: 2023-06-02, Last updated: 2023-06-06 | ||
| 520 | |a The invention discloses application of tetrahydropalmatine in preparation of a coronavirus infection resisting medicine, and belongs to the technical field of medicine. According to the application disclosed by the invention, the tetrahydropalmatine is found to be capable of inhibiting the replication of the pathogenic coronaviruses HCoV-OC43 and HCoV-229E on Huh-7 cells, and the median effective inhibitory concentration (EC50) values of the tetrahydropalmatine are 8.87 [mu]M and 28.80 [mu]M respectively. Meanwhile, the tetrahydropalmatine can effectively reduce the virus titers of HCoV-OC43 and HCoV-229E in Huh-7 cells, the virus inhibition rates are 92.16% and 93.79% respectively after 72 hours of administration under the condition that the maximum administration dosage is 60 [mu]M, and the tetrahydropalmatine has important application prospects in the aspect of clinical treatment or prevention of coronavirus infection. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a LIN QISHENG |4 aut | |
| 700 | 0 | |a CHENG ZIYU |4 aut | |
| 700 | 0 | |a SONG GAOPENG |4 aut | |
| 700 | 0 | |a JIA WEIXIN |4 aut | |
| 700 | 0 | |a MA YONGJIANG |4 aut | |
| 700 | 0 | |a SHAN HAIKUO |4 aut | |
| 700 | 0 | |a YANG XIA |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2022) vom: 18. Feb. |
| 773 | 1 | 8 | |g year:2022 |g day:18 |g month:02 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/80271808/publication/CN114053273A1?q=CN114053273 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 936 | u | w | |j 2022 |b 18 |c 02 |
| 951 | |a AR | ||
| 952 | |j 2022 |b 18 |c 02 | ||