Modification method of mesoporous SiO2 material
The invention discloses a modification method of a mesoporous SiO2 material. The method comprises the following specific steps: oxidizing terminal hydroxyl of alkylphenol polyoxyethylene ether into carboxyl by using KMnO4, and then conducting chlorinating to form acyl chloride by using SOCl2; subjecting hydroxyl on the surface of the mesoporous SiO2 material to hydrophobic modification with gamma-aminopropyltriethoxysilane, so as to obtain a gamma-site amino structure; and constructing amido bonds to complete oil-water amphiphilic modification. The alkylphenol polyoxyethylene ether is octylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether or dodecyl polyoxyethylene ether, and the polymerization degree of a polyoxyethylene chain is 8-20. The modification method is suitable for nano fumed silica, monodisperse mesoporous SiO2 microspheres, mesoporous SiO2 molecular sieves and the like. Compared with an unmodified or conventional hydrophobic modified mesoporous SiO2 material, the mesoporous SiO2 material modified according to the method has hydrophilic and oleophylic amphipathy, can be well dispersed in water and an organic solvent, and can simultaneously realize loading and effective release of water-soluble and fat-soluble drugs when being used as a drug carrier material..
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 11. Feb. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
CHEN BO [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-02-11, Last update posted on www.tib.eu: 2022-09-07, Last updated: 2023-02-09 |
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| Patentnummer: |
CN114028575 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA013475940 |
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| 520 | |a The invention discloses a modification method of a mesoporous SiO2 material. The method comprises the following specific steps: oxidizing terminal hydroxyl of alkylphenol polyoxyethylene ether into carboxyl by using KMnO4, and then conducting chlorinating to form acyl chloride by using SOCl2; subjecting hydroxyl on the surface of the mesoporous SiO2 material to hydrophobic modification with gamma-aminopropyltriethoxysilane, so as to obtain a gamma-site amino structure; and constructing amido bonds to complete oil-water amphiphilic modification. The alkylphenol polyoxyethylene ether is octylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether or dodecyl polyoxyethylene ether, and the polymerization degree of a polyoxyethylene chain is 8-20. The modification method is suitable for nano fumed silica, monodisperse mesoporous SiO2 microspheres, mesoporous SiO2 molecular sieves and the like. Compared with an unmodified or conventional hydrophobic modified mesoporous SiO2 material, the mesoporous SiO2 material modified according to the method has hydrophilic and oleophylic amphipathy, can be well dispersed in water and an organic solvent, and can simultaneously realize loading and effective release of water-soluble and fat-soluble drugs when being used as a drug carrier material. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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